Universitetet i Oslo

Oslo

Luiza Angheluta-Bauer

Professor

For questions regarding the recruitment system, please contact Karoline Hanssen 

HR Consultant 

<h2>About the position</h2>A PhD Research Fellowship is available at the Department of Physics, Faculty of Mathematics and Natural Sciences, University of Oslo, within the interdisciplinary research team <a href="https://www.uio.no/english/research/strategic-research-areas/life-science/research/convergence-environments/glioforce/" rel="nofollow">GLIOFORCE</a> – Targeting Cellular Biomechanics to Block Tumour Cell Invasion. GLIOFORCE is a newly established Life Science Convergence Environment that brings together physics, biomedicine, engineering, and pharmacy to address fundamental challenges in cancer research. Starting date no later than September 15, 2026. The fellowship period is four years, including 25 % of other career-promoting work. This may involve teaching and/or project-related activities such as contributing to consortium seminars, maintaining project websites, laboratory assistance, or other tasks that support the research environment. No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo. <h2>Job description</h2>Glioblastoma (GBM) is a highly invasive and lethal brain cancer whose progression is strongly governed by cellular and nuclear mechanics, cytoskeletal organization, and interactions with a mechanically heterogeneous brain microenvironment. The GLIOFORCE project explores mechano-adaptation as a targetable vulnerability in this aggressive disease. The successful candidate will join an interdisciplinary research consortium and work closely with three other PhD students, combining theory, computation, and experiments to model and manipulate the physical forces experienced by invading cancer cells. The overarching goal is to identify biomechanical “weak points” in cancer cell invasion and to inform the development of innovative, mechanics-based intervention strategies. By focusing on the biomechanics of cancer cell spreading, GLIOFORCE seeks to open new avenues for the treatment of aggressive cancers such as glioblastoma. Within this framework, the present PhD fellow will develop and analyze active-matter physics models of GBM cell deformation and invasion, with particular emphasis on identifying biomechanical tipping points at which invasion becomes mechanically unfeasible. The work of the PhD fellow will be theoretical and computational in nature and include:  <ul><li>Developing physics-based, deformable cell models of glioblastoma invasion that incorporate nuclear and cytoskeletal mechanics</li><li>Applying active-matter theory to describe transitions between collective and singlecell invasion in confined and mechanically heterogeneous environments</li><li>Calibrating and validating models using experimental data from imaging, biosensors, and microchannel assays, in close collaboration with experimental partners</li><li>Identifying biomechanical regime shifts and tipping points, and contributing to an open-source computational framework for cancer invasion modelling</li></ul>The project offers a highly interdisciplinary research environment spanning physics, cell biology, materials science, and advanced imaging. <h2>What skills are important in this role?</h2>The Faculty of Mathematics and Natural Sciences has a strategic ambition to be among Europe’s leading communities for research, education and innovation. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.Required qualifications:<ul><li>Master’s degree or equivalent in physics, applied mathematics, computational science, or a closely related field</li><li>Foreign completed degree (M.Sc.-level) corresponding to a minimum of four years in the Norwegian educational system</li><li>Strong background in theoretical modelling, preferably within active matter physics</li><li>Solid programming skills</li></ul>Desired qualifications:<ul><li>Experience in statistical physics, solid mechanics, or fluid mechanics</li><li>Experience with data-driven modeling, parameter estimation, or model calibration</li><li>Familiarity with high-performance computing or large-scale simulations</li><li>Interest in close collaboration with experimental researchers</li></ul>Language requirement:<ul><li>Good oral and written communication skills in English</li><li>English requirements for applicants from outside of EU/ EEA countries and exemptions from the requirements: <a href="https://www.mn.uio.no/english/research/phd/regulations/regulations.html#toc8" rel="nofollow">https://www.mn.uio.no/english/research/phd/regulations/regulations.html#toc8</a></li></ul>Grade requirements: The norm is as follows:<ul><li>The average grade point for courses included in the Bachelor’s degree must be C or better in the Norwegian educational system</li><li>The average grade point for courses included in the Master’s degree must be B or better in the Norwegian educational system</li><li>The Master’s thesis must have the grade B or better in the Norwegian educational system</li></ul>The purpose of the fellowship is research training leading to the successful completion of a PhD degree. For more information see: <a href="https://www.mn.uio.no/english/research/phd/" rel="nofollow">http://www.mn.uio.no/english/research/phd/</a>All candidates and projects will have to undergo a check versus national export, sanctions and security regulations. Candidates may be excluded based on these checks. Primary checkpoints are the Export Control regulation, the Sanctions regulation, and the national security regulation. <h2>What are we looking for in you?</h2>Personal skills:<ul><li>Strong analytical skills and scientific curiosity</li><li>Open-minded, collegial, and comfortable engaging in a social and interdisciplinary research environment</li><li>High level of motivation, responsibility and perseverance</li><li>Clear and constructive scientific communication skills</li></ul>Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications. <h2>We can offer you</h2><ul><li>A pleasant and stimulating work environment</li><li>Good <a href="https://www.uio.no/english/for-employees/employment/welfare/index.html" rel="nofollow">welfare schemes</a></li><li>Opportunity of up to 1.5 hours a week of <a href="https://www.uio.no/english/for-employees/employment/welfare/exercise/" rel="nofollow">exercise during working hours</a></li><li>A workplace with good development and career opportunities</li><li><a href="https://www.mn.uio.no/english/research/phd/career-support/index.html" rel="nofollow">Career development programmes</a></li><li>Membership in the <a href="https://www.spk.no/en/" rel="nofollow">Statens Pensjonskasse,</a> which is one of Norway&#39;s best pension schemes with beneficial mortgages and good insurance schemes</li><li>Oslo’s family-friendly surroundings with their rich opportunities for culture and outdoor activities</li><li>Salary in position as PhD Research Fellow, position code 1017 in salary range NOK from 550 800 - 595 000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund </li></ul> <h2>We need different perspectives in our work</h2>UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at <a href="https://www.uio.no/english/about/strategy/gender-equality/index.html" rel="nofollow">uio.no</a>.We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues, could you be the next one?We will do our best to accommodate your needs. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.If you have an <a href="https://lovdata.no/dokument/SF/forskrift/2017-06-21-838/%C2%A74#%C2%A74" rel="nofollow">immigrant background, a disability, or CV gaps</a> (Norwegian), we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the <a href="https://arbeidsgiver.dfo.no/strategisk-hr/inkluderingsarbeid/bli-bedre-pa-rekruttering/hvordan-skrive-stillingsannonser-som-inkluderer/positiv-saerbehandling-nar-man-soker-jobb-i-staten" rel="nofollow">Employer portal</a> (Norwegian).The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports.  We hope you will apply for the position with us. <h2>How to apply</h2>The application must include:<ul><li>Cover letter- statement of motivation and research interests</li><li>CV (summarizing education, positions, research experience, pedagogical experience, and other relevant activities)</li><li>Copies of educational certificates, academic transcript of records and letters of recommendation</li><li>List of publications and academic work that the applicant wishes to be considered by the evaluation committee, including exercises or problem sets the applicant has designed </li><li>Names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number)</li><li>Documentation of English proficiency if applicable</li></ul>Application with attachments must be submitted via our recruitment system Jobbnorge, click &#34;Apply for this job&#34;.When applying for the position, we ask you to retrieve your education results from <a href="https://www.vitnemalsportalen.no/english/" rel="nofollow">Vitnemålsportalen.no</a>. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language. <h2>General information</h2>The best qualified candidates will invited for interviews. Applicant lists can be published in accordance with <a href="https://lovdata.no/dokument/NLE/lov/2006-05-19-16" rel="nofollow">Norwegian Freedom of Information Act § 25</a>. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we can&#39;t, you will hear from us. Please refer to <a href="https://www.uio.no/english/about/regulations/personnel/academic/guidelines-appointment-postdoc-researcher.html" rel="nofollow">Regulations for the Act on universities and colleges chapter 3</a> (Norwegian), <a href="https://www.uio.no/english/about/regulations/personnel/academic/guidelines-appointment-postdoc-researcher.html" rel="nofollow">Guidelines concerning appointment to post doctoral and research posts at UiO</a> (Norwegian) and <a href="https://www.uio.no/english/about/regulations/research/doctoral-degree/phdforskreng.html" rel="nofollow">Regulations for the degree of Philosophiae Doctor (PhD) at the University of Oslo</a>.  The University of Oslo has a <a href="https://www.uio.no/english/for-employees/employment/work-results/agreement-rights-to-work-results.html" rel="nofollow">transfer agreement</a> with all employees that is intended to secure the rights to all research results etc.

PhD Research Fellow in Theoretical and Computational Active Matter Physics for Glioblastoma Invasion